Tetraethylthiuram disulfide, also known as disulfiram, also known as disulfuron (commercially known as disulfiram or Antabuse) is a drug discovered in the 1920s because of its immediate effect on alcohol. It is used to treat chronic alcohol addiction. When we drink alcohol (ethanol), ethanol is converted into acetaldehyde by the action of alcohol dehydrogenase in the liver, and acetaldehyde is then converted into acetic acid by the action of acetaldehyde dehydrogenase, and finally acetic acid is converted into H20 and CO2 through the citric acid cycle. in vitro. Dithiolon inhibits the conversion of acetaldehyde into acetic acid by inhibiting the action of acetaldehyde dehydrogenase, which can cause accumulation of acetaldehyde and cause physical discomfort. It must be used with a doctor's prescription. In addition to alcohol, disulfide is also used in the treatment of cocaine withdrawal because of its ability to prevent the decomposition of dopamine. Dopamine is a neurotransmitter produced by the stimulation of cocaine. Excessive dopamine intake can cause anxiety, high blood pressure, restlessness, and other uncomfortable symptoms. Some studies even show that dopamine has antiprotozoal activity. In addition, academically, dithiolon is the subject of research for the treatment of cancer and HIV (dithiolon can activate HIV-infected, but dormant CD4 cell reservoirs)
Chinese name: Tetraethylthiuram disulfide
English name: Tetraethylthiuram Disufide
Also called: accelerator TETD tetraethyl thioperoxydicarbonate diamide
Chemical formula: C10H20N2S4
Molecular weight: 296.55
CAS Registry Number: 97-77-8
EINECS accession number: 202-607-8
Melting point (ºC): 65～70
Water solubility: insoluble in water, slightly soluble in acetone, soluble in benzene, chloroform, carbon disulfide.
Degree of density (g/mL, 20°C): 1.17
External view: yellow and white crystals
Application: Used to manufacture cables, medical supplies, adhesive tape, rubber shoes, inner tubes, bright color products, etc.
Security description: S24 S37 S60 S61
Hazard symbol: R22 R43 R48/22 R50/53
Dangerous goods transport code: UN 3077 9/PG 3